Yesung Carier (Part 2)

In July 2010, Yesung appeared with band mate Leeteuk as MC's for MBC's Love Pursuer. The show presents a Korean celebrity being showered with affection from a secret admirer, with the challenge of guessing who the admirer is. Yesung was himself the subject of admiration in episode 10. During the recording of Dream Team 2 on 21 August 2011, he fell from a platform and strained his waist again, but was reported to be a minor injury. on 4 September, he became a new MC for MUZIT, a musical talk show alongside K.Will and veteran composer Yoo Youngsuk. It showcased various musical talents from the Korean music industry.

From 1 October to 28 October 2010, also he starred in his third musical Spamalot playing the main role of Sir Galahad.

On 29 December, Yesung together with Luna of f(x), sang the track " Loving You", on part two of the original soundtrack of KBS drama President.

2011 : DJ and Super Junior K.R.Y Concert and Why Style Eye wear

On 31 January 2011, Yesung's third solo song, from the OST of SBS drama, Paradise Ranch, was released. "Waiting For You" is ballad that tells the story of man who is adamant on waiting until the end of the world for his lover to return to him. He performed it for the first time at the K.R.Y Concert in Seoul on 11 February.

From 28 February to 21 June 2011, Yesung temporarily replaced band mate Eunhyuk as radio DJ partnering with Leeteuk on Super Junior's Kiss the Radio, while Eunhyuk was away on promotional activities for Super Junior's M third EP Perfection. In June, he joined KBS's Immortal Song 2 where singers render their own versions of old songs from music legends and winners are selected by voting. He lost in thefirst episode but won the third episode when he sang Boohwal's song "The More I Love".

His second duet with Jang Hye Jin, was released on 14 July 2011 throughout Korea's digital charts. "I Am Behind You " is from the album Cooperation Part 1. The song as a fantastic harmony and is mixed with the lyricks of secretly loving someone and wondering if that person could possibly be feeling the same way about them. On 18 July 2011, "For One Day" was released. It is from the OST SBS historical drama Warrior Baek Dong Soo. The song explores an emotional farewell from a lover. Yesung performed this live for the first time on 6 October 2011 at the K.R.Y Concert in Nanjing.